Genome Architecture

Genome architecture is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.

A gene is the entire nucleic acid sequence that is necessary for the controlled production of its final product (RNA or Protein). The basic unit of genome architecture is gene these correspond to specific regions in chromosomes (genome), these regions are further organized exons/introns, transcripts, promoter regions, Repetitive regions, Telomeres, centromeres, CpG Islands. In Prokaryotic most bacterial genomes are carried in one circular chromosome Stable replication requires one replication origin (ORI) The Genome is packed with polyamines (stabilizing proteins), In Eukaryotic: The genome is distributed over several linear chromosomes Stable replication occurs from several replication origins within each chromosome, and additionally requires centromeres, Telomeres.

Genetic architecture, the structure of the mapping from genotype to phenotype, determines the variational properties of the phenotype and is instrumental in understanding its evolutionary potential. Throughout most of the history of evolutionary biology, genetic architecture has been treated as a given set of parameters and not as a set of dynamic variables.

Conferences related to Genome Architecture are Genome Architecture in Cell Fate & Disease, The Chinese University of Hong Kong, China- Conference on Genome Architecture, ICTP, Trieste, Italy- The Genomics of Common Diseases, Cambridge, UK- Plant Genomes & Biotechnology: From Genes to Networks, NY, USA- Rat Genomics & Models, NY, USA- CSHL meeting: Genome Informatics, NY, USA- Maintenance of Genome Stability 2016, Panama- Central America- 18th International Conference on Quantitative Genetics and Genomics, London, UK- At the intersection of DNA replication and genome maintenance: from mechanisms to therapy, Trieste, Italy- Abcam Conference "Mechanisms of Recombination", Alicanta, Spain.

  • The Complex Genome
  • Nuclear Architecture in Disease
  • Transcription and Genome Organization
  • Developmental architecture
  • Differentiation & Development
  • De Novo Origination
  • Stem cell formation
  • Stem cell formation

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