GPCRs Drug Discovery

G protein-coupled receptors (GPCRs) belong to a great domestic of cell surface signaling proteins that have a pivotal role in many biological functions and in multiple diseases, including the development of cancer and cancer metastasis. Naturally, a number of drugs based on GPCRs have been industrialized for such different indications as cardiovascular, metabolic, neurodegenerative, psychiatric, and oncologic diseases. Owing to the restricted structural information on GPCRs, only limited exploration of structure-based drug design has been possible. Current drugs that target GPCRs - many of which have tremendous therapeutic benefits - are directed towards only a few GPCR members. Therefore, huge determinations are currently proceeding to develop new GPCR-based drugs. We review recent findings that present unexpected opportunities to interfere with main tumorigenic signals by manipulating GPCR-mediated pathways. We also discuss current data concerning novel GPCR targets that may provide talented opportunities for drug discovery in cancer prevention and treatment.

G protein-coupled receptors (GPCRs) belong to a great domestic of cell surface signaling proteins that have a pivotal role in many biological functions and in multiple diseases, including the development of cancer and cancer metastasis. Naturally, a number of drugs based on GPCRs have been industrialized for such different indications as cardiovascular, metabolic, neurodegenerative, psychiatric, and oncologic diseases. Owing to the restricted structural information on GPCRs, only limited exploration of structure-based drug design has been possible. Current drugs that target GPCRs - many of which have tremendous therapeutic benefits - are directed towards only a few GPCR members. Therefore, huge determinations are currently proceeding to develop new GPCR-based drugs. We review recent findings that present unexpected opportunities to interfere with main tumorigenic signals by manipulating GPCR-mediated pathways. We also discuss current data concerning novel GPCR targets that may provide talented opportunities for drug discovery in cancer prevention and treatment.

  • GPCR Signaling
  • Targeting Drug on GPCR
  • Novel Targeting on GPCR
  • GPCR Crystallography in Drug Discovery
  • GPCR Structures in Drug Discovery
  • Tools for GPCR Drug Disocvery
  • Biosensors GPCR Probing Conformation
  • GPCR Screening Method for Drug Discovery

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