Hematopoietic stem cells

Hematopoietic stem cells (HSCs) are the stem cells that give rise to blood cells through the operation of hematopoiesis. They are obtained from mesoderm and located in the red bone marrow, which is contained in the core of most bones. Hematopoiesis is the process by which all mature blood cells are produced. It must balance extensive production needs (>500 billion blood cells are produced every day) with the need to absolutely regulate the number of each blood cell type in the circulation. In vertebrates, the extensive majority of hematopoiesis occurs in the bone marrow and is obtained from a limited number of hematopoietic stem cells (HSCs) that are multipotent and capable of immeasurable self-renewal.

  • Hematopoiesis
  • Stem cell heterogeneity
  • Multipotency and self-renewal
  • Cluster differentiation and other markers
  • Cluster differentiation and other markers
  • Hematopoietic colonies and lineages
  • HSC repopulation kinetics

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