Histone Modifications and Cancer

Cancer is considered to have a clonal origin but cancer tissues are comprised of a heterogeneous group of cells with different functional potential. Alterations in the modifications of histones have been linked to deregulated expression of many genes with important roles in cancer development and progression. Histones are the class of proteins bundled within a DNA that promote the effects of DNA methylation on gene expression indirectly. In contrast to the stable effects of DNA methylation, histone modifications have greater plasticity in determining the expression or silencing of specific genes in response to stimuli.

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