HIV Drug Discovery and Research

The development of drugs for HIV infection began soon after the virus was discovered 25 years ago. Since then, progress has been substantial, but numerous uncertainties persist about the best way to manage this disease. Here we review the current treatment options, consider novel mechanisms that can be exploited for existing drug targets, and explore the potential of novel targets. With a view to the next quarter century, we consider whether drug resistance can be avoided, which drug classes will be favoured over others, which strategies are most likely to succeed, and the potential impact of pharmacogenomics and individualized therapy.

HIV infection and AIDS have become a major worldwide public health problem. According to WHO approximately 35 million people worldwide living with HIV/AIDS in 2013, unaware of the outcomes. AIDS (acquired immunodeficiency syndrome) is a chronic, potentially life-threatening condition caused by the human immunodeficiency virus (HIV) which damages the immune system and, interferes with body's ability to fight the organisms that cause disease

Classes of drugs and mechanism

Immunology and strategies towards HIV and retroviral infections

HIV/AIDS and STDs/STIs: Vaccines research and development

Nucleoside analogues and molecular mechanisms

HIV: Current pharmaceutical design

  • Classes of drugs and mechanism
  • Immunology and strategies towards HIV and retroviral infections
  • HIV/AIDS and STDs/STIs: Vaccines research and development
  • Nucleoside analogues and molecular mechanisms
  • HIV: Current pharmaceutical design

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