HIV Drug Discovery & Research

The development of drugs for HIV infection initiated rapidly after the virus was discovered 25 years ago. Since then, progress has been substantial, but numerous uncertainties persist about the best way to achieve this disease. Here we review the current treatment opportunities, consider novel mechanisms that can be exploited for existing drug targets, and explore the potential of novel targets. With a view to the next quarter century, we reflect whether drug resistance can be avoided, which drug classes will be favoured over others, which strategies are most likely to succeed, and the prospective impact of pharmacogenomics and individualized therapy.

The development of drugs for HIV infection initiated rapidly after the virus was discovered 25 years ago. Since then, progress has been substantial, but numerous uncertainties persist about the best way to achieve this disease. Here we review the current treatment opportunities, consider novel mechanisms that can be exploited for existing drug targets, and explore the potential of novel targets. With a view to the next quarter century, we reflect whether drug resistance can be avoided, which drug classes will be favoured over others, which strategies are most likely to succeed, and the prospective impact of pharmacogenomics and individualized therapy.

  • Classes of drugs and mechanism
  • Vaccines research and development
  • Current pharmaceutical design
  • Immunology and strategies towards HIV and retroviral infections
  • Nucleoside analogues and molecular mechanisms

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