Hyphenated Techniques

Hybrid separation techniques or hyphenated techniques is the combination of mass spectrometry and chromatography in which the particles can be detected and then separated accordingly by chromatographic separation technique. The term Hyphenated techniques ranges from the blend of division ID, hyphenated systems, e.g., GC-MS, LC-MS, LC-FTIR, LC-NMR, CE-MS, and so forth. Hyphenated procedures along with chromatographic and ghostly techniques to abuse the benefits of both partition detachment methods. These systems demonstrate specificity and affectability. A Hyphenated system is mix or coupling of two distinctive systematic strategies with the assistance of two legitimate interfaces.  Advancements in hybrid separation techniques over the past decade has significant outgrowth which added a new dimension to the separation techniques especially for the analysis of biomaterials. 

Hybrid separation techniques or hyphenated techniques is the combination of mass spectrometry and chromatography in which the particles can be detected and then separated accordingly by chromatographic separation technique. The term Hyphenated techniques ranges from the blend of division ID, hyphenated systems, e.g., GC-MS, LC-MS, LC-FTIR, LC-NMR, CE-MS, and so forth. Hyphenated procedures along with chromatographic and ghostly techniques to abuse the benefits of both partition detachment methods

  • Applications of hyphenated separation techniques
  • Gas chromatography -mass spectrometry (GC/MS or GC-MS)
  • Liquid chromatography-mass spectrometry (LC/MS OR LC-MS)
  • Capillary electrophoresis-mass spectrometry
  • Liquid chromatography-NMR spectroscopy. (LC-NMR)
  • LC-NMR-MS
  • Liquid chromatography-infrared spectroscopy(LC-IR)
  • Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
  • Gas chromatography-infrared spectroscopy (GC-IR)
  • MALDI-TOF matrix-assisted laser desorption/ionization mass spectrometry
  • HPLC-ESI-MS / HPLC-CE-MS - mass spectrometry
  • LC-NMR-MS / LC-ESI-MS - mass spectrometry
  • Liquid Chromatography LC-PDA
  • Solid state Nuclear magnetic resonance - NMR

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