Immune checkpoint inhibitors

Immunology-based therapy is rapidly developing into an effective treatment option for a surprising range of cancers. We have learned over the last decade that powerful immunologic effector cells may be blocked by inhibitory regulatory pathways controlled by specific molecules often called "immune checkpoints." The development of a new therapeutic class of drugs that inhibit these inhibitory pathways has recently emerged as a potent strategy in oncology. Three sets of agents have emerged in clinical trials exploiting this strategy. These agents are antibody-based therapies targeting cytotoxic T-lymphocyte antigen 4 (CTLA4), programmed cell death 1 (PD-1), and programmed cell death ligand 1 (PD-L1). These inhibitors of immune inhibition have demonstrated extensive activity as single agents and in combinations. Clinical responses have been seen in melanoma, renal cell carcinoma, small cell lung cancer, and several other tumor types.

 One of the most exciting aspects of checkpoint inhibition in cancer therapy is that, unlike conventional cytotoxic drugs and targeted agents, it has the potential to work universally in all cancers. Checkpoint inhibitors, alone or in combination, have yielded promising results not only in advanced melanoma and RCC but also in triple-negative breast cancer and cancers of the prostate, bladder, lung, and head and neck.

  • Drugs
  • Recognision of immune cells
  • Attacking mechanisms
  • Adverse effects of these drugs
  • Considerations in Using/Prescribing
  • PD-1 or PD-L1 Targetors/Targets
  • Targetting CTLA-4

Related Conference of Immune checkpoint inhibitors

December 14-15, 2017

World Immunology Congress

Dubai, UAE
April 19-20, 2018

7th World Congress on Immunology

Amsterdam, Netherlands
May 16-17, 2018

World Congress on Allergy and Immunotherapy

Osaka, Japan
June 14-16 2018

9th European Immunology Conference

Rome, Italy
July 05-07, 2018

EuroSciCon Conference on Immunology Conference 2018

Vienna, Austria
July 12-13, 2018

5th International Conference on Parasitology

Paris, France
August 06-07, 2018

International Immunology Conference

Dubai, UAE
September 13-14, 2018

Annual Congress on Immunology & Immunotechnology

Zurich, Switzerland
September 24-26, 2018

International Conference on Hepatitis

Amsterdam, Netherlands
October 19-20, 2018

10th World Congress and Expo on Immunology

Baltimore, USA
October 29-30, 2018

6th International Conference on HIV/AIDS, STDs and STIs

San Francisco, USA
November 26-27, 2018

3rd International Conference on Autoimmunity

Dublin, Ireland

Immune checkpoint inhibitors Conference Speakers