Immune Checkpoints

The immune system plays a dual role against cancer: it prevents tumor cell outgrowth and also sculpts the immunogenicity of the tumor cells. Cancer cells are able to escape from the immune system by inhibiting T lymphocytes activation. New immunotherapies have been developed to target these T lymphocytes activation modulators: the immune checkpoints, defined as molecules of immune system that either turn up a signal or turn down a signal. Most of the cancers protect themselves from immune system by inhibiting activation of T cell.

 These novel therapies are showing promising results with durable objective responses in some patients. Ipilimumab (anti-CTLA4) was the first of these new therapeutics to be approved by the FDA in March 2011 for advanced melanoma and other immunomodulators trials are ongoing in other cancers with similar encouraging results like with the anti PD-1/PD-L1. These drugs are already challenging our future practice like for evaluation of tumor response or for management of immune related toxicities. Many immune checkpoints have been identified and could potentially be targeted. Future studies will help to identify predictive factors but also to coordinate these new immunotherapies with our classic treatment strategies.

  • Immune checkpoint therapy
  • Immune modulators
  • Inhibitory immune checkpoints
  • Stimulatory immune checkpoints
  • Anti tumor immune response

Related Conference of Immune Checkpoints

November 2-3, 2017

9th World Congress and Expo on Immunology

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November 02-03, 2017

9th World Congress on Immunity, Inflammation and Immunotherapies

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2nd International Conference on Autoimmunity

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3rd Antibodies and Bio Therapeutics Congress & B2B

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World Immunology Congress

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7th World Congress on Immunology

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World Congress on Allergy and Immunotherapy

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9th European Immunology Conference

June 14-16, 2018 Rome, Italy
July 05-07, 2018

EuroSciCon Conference on Immunology Conference 2018

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July 12-13, 2018

5th International Conference on Parasitology

Paris, France

Immune Checkpoints Conference Speakers

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