Immune mediators and thier role in vitiligo

The precise cause of vitiligo is still unclear. Multiple theories have been proposed, including genetic, autoimmune, neural, and biochemical mechanisms. An immune mediated pathogenesis is indeed the most popular theory. The autoimmune hypothesis considers the role of toxic mediator that might cause an injury to the melanocytes with the release of an antigenic substance and subsequent autoimmunization. Histamine appears to play a significant role in the pathogenesis of a particular type of vitiligo characterized by faint hypo pigmented patches with significant itching.

  • vitiligo universalise
  • non- skin melanocytes in vitiligo
  • vitiligo and immune deficiency
  • inherited diseases in vitiligo
  • inherited diseases in vitiligo
  • neurogenic hypotheses in vitiligo

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