Immune Tolerence

Immunological tolerance is the failure to mount an immune response to an antigen. It can be: Natural or "self" tolerance. This is the failure (a good thing) to attack the body's own proteins and other antigens. If the immune system should respond to "self", an autoimmune disease may result.Natural or "self" tolerance: This is the failure (a good thing) to attack the body's own proteins and other antigens. If the immune system should respond to "self", an autoimmune disease may result. Induced tolerance: This is tolerance to external antigens that has been created by deliberately manipulating the immune system. 

  • Immune homeostasis: Immunity versus tolerance
  • Immune modulation of tumors
  • Central nervous system-targeted autoimmunity
  • Tissue-specific autoimmunity
  • B cell differentiation pathways and disease susceptibility
  • Transplant rejection and engraftment
  • Next generation immune-based therapies

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