Immunodeficiences

Immunodeficiency is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent. Immunodeficiency disorders prevent your body from adequately fighting infections and diseases. An immunodeficiency disorder also makes it easier for you to catch viruses and bacterial infections in the first place. Immunodeficiency disorders are often categorized as either congenital or acquired. A congenital, or primary, disorder is one you were born with. Acquired, or secondary, disorders are disorders you get later in life. Acquired disorders are more common than congenital disorders. Immune system includes the following organs: spleen, tonsils, bone marrow, lymph nodes. These organs make and release lymphocytes. Lymphocytes are white blood cells classified as B cells and T cells. B and T cells fight invaders called antigens. B cells release antibodies specific to the disease your body detects. T cells kill off cells that are under attack by disease. An immunodeficiency disorder disrupts your body’s ability to defend itself against these antigens. Types of immunodeficiency disorder are Primary immunodeficiency disorders & Secondary  immunodeficiency  disorders.

Primary immunodeficiency disorders are immune disorders you are born with. Primary disorders include:

X-linked agammaglobulinemia (XLA)

·         Common variable immunodeficiency (CVID)

·         Severe combined immunodeficiency (SCID)

Secondary disorders happen when an outside source, such as a toxic chemical or infection, attacks your body. Severe burns and radiation also can cause secondary disorders.

Secondary disorders include: AIDS, cancers of the immune system  such as leukemia, immune-complex diseases such as viral hepatitis, multiple myeloma.

 

Primary immunodeficiency disorders are immune disorders you are born with. Primary disorders include:

X-linked agammaglobulinemia (XLA)

·         Common variable immunodeficiency (CVID)

·         Severe combined immunodeficiency (SCID)

Secondary disorders happen when an outside source, such as a toxic chemical or infection, attacks your body. Severe burns and radiation also can cause secondary disorders.

Secondary disorders include: AIDS, cancers of the immune system  such as leukemia, immune-complex diseases such as viral hepatitis, multiple myeloma.

 

  • Congenital/Acquired immunodeficiency
  • Immune system and primary/secondary immunodeficiences
  • T cell and B cell immunodeficiency
  • Severe combined immunodeficiency
  • MHC deficiencies

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