Immunodeficiency and Autoimmunity

Immunodeficiency is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent. Immunodeficiency may also decrease cancer immunosurveillance. Most cases of immunodeficiency are acquired  but some people are born with defects in their immune system, or primary immunodeficiency. Transplant patients take medications to suppress their immune system as an anti-rejection measure, as do some patients suffering from an over-active immune system. A person who has an immunodeficiency of any kind is said to be immunocompromised. Animmunocompromised person may be particularly vulnerable to opportunistic infections, in addition to normal infections that could affect everyone. There are a large number of immunodeficiency syndromes that present clinical and laboratory characteristics of autoimmunity. The decreased ability of the immune system to clear infections in these patients may be responsible for causing autoimmunity through perpetual immune system activation.

Immunodeficiency is one cause of multigenic autoimmune diseases, including the role of HLA genes and the thymus, were reviewed elsewhere and are not discussed here. The use of bone marrow transplantation (BMT) in the treatment of severe primary immunodeficiencies, a procedure that may either precipitate or ameliorate autoimmunity, was recently extensively reviewed. Mostly because of Autoimmunity Immunodeficiancy are accur in the Autoimmun suffering persons.

  • Common Variable Immune Deficiency [CVID]
  • Immune System Dysfunction
  • Immunoreceptors Mutation

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