Immunoproteomics

Immunoproteomics is the study of large sets of proteins (proteomics) involved in the immune response like the isolation and mass spectrometric identification of MHC (major histocompatibility complex) binding peptides, purification and identification of protein antigens binding specific antibodies (or other affinity reagents), comparative immunoproteomics to identify proteins and pathways modulated by a specific infectious organism, disease or toxin. The identification of proteins in immunoproteomics is carried out by techniques including gel based, microarray based, and DNA based techniques, with mass spectroscopy typically being the ultimate identification method

Serum antibody identification in particular has proven to be very useful as a diagnostic tool for a number of diseases in modern medicine (in large part due to the relatively high stability of serum antibodies).

• Computational immunology
• Systems immunology
• Epigenetics of trained innate immunity
• Applied immunology and immunotherapy
• Application of proteomics in autoimmune diseases

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