Infection and Autoimmunity

 

Particular viruses, bacteria and other infectious pathogens are the major postulated environmental triggers of autoimmunity. The pathogen may carry elements that are similar enough in amino acid sequence or structure to self-antigen that the pathogen acts as a  ‘molecular mimicry’, T or B cells that are activated in response to the pathogen are also cross-reactive to self and lead to direct damage and further activation of other arms of the immune system. The pathogen may also lead to disease via epitope spreading. In this model the immune response to a persisting pathogen, or direct lysis by the persisting pathogen, causes damage to self-tissue. Persistent viral infections can lead to immune-mediated injury due to the constant presence of viral antigen driving the immune response or Virus-Host Interactions,

,Infectious diseases are sometimes called contagious disease when they are easily transmitted by contact with an ill person or their secretions (e.g., influenza). Thus, a contagious disease is a subset of infectious disease that is especially infective or easily transmitted. Other types of infectious/transmissible/communicable diseases with more specialized routes of infection, but Autoimmunological disease are not transmitted by contact.

  • Microbial Infection
  • Viral and Bacterial Super Antigens
  • Virus-Host Interactions
  • Persistent of Infection and Autoimmunity

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Infection and Autoimmunity Conference Speakers