Interrogating Cancer Genes with NGS-Based Approaches

Next-generation sequencing (NGS) technologies and knowledge have revolutionized cancer analysis and are increasingly being deployed to guide clinicians in treatment decision-making. NGS technologies have allowed taking an “omics” approach to cancer in order to reveal genomic, transcriptomic, and epigenomic landscapes of individual malignancies. Integrative multi-platform analyses are more and more utilized in large-scale projects that aim to completely characterize individual tumours still as general cancer sorts and subtypes. NGS technologies especially have contributed to “omics” approaches in cancer analysis, allowing large-scale integrative analyses that take into account many neoplasm samples. These types of studies have provided us with an unprecedented wealth of information, providing the background knowledge needed to make small-scale studies informative and relevant. Cancer analysis and care are presently poised to expertise vital progress catalyzed by accessible sequencing technologies which will profit each clinical and research-based effort.

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