Liver Growth and repair

The liver is the main instinctive organ that has the astounding ability to recover. The liver can recover after either surgical removal or after chemical injury. It is known that as little as 25% of the original liver mass can recover back to its full size. The process of recovery in mammals is essentially compensatory development because lone the mass of the liver is replaced, not the shape. However, in lower species, for example, fish, both liver size and shape can be replaced. Liver recovery includes replication of the liver cells, mainly hepatocytes, followed by other cells such as biliary epithelial cells and sinusoidal endothelial cells. When cell proliferation is finished, the recently isolated cells experience rebuilding, angiogenesis and renewal of extracellular matrix to finish the recovery procedure. Strikingly, much of the time, liver function is only partially affected during liver recovery. While certain functions, for example, drug metabolism decrease, many other primary functions such as albumin and bile production are not substantially influenced

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