Mechanisms of Signal Transduction
Signal transduction occurs when an extracellular signalling molecule activates Protein phosphorylation networks located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events like G-proteins in cellular regulation inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism and Mechanisms of signalling specificity in cell fate, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signalling molecule can cause many responses like control of dna replication initiation and genomic stability.
3rd World Congress on Pharmacology, August 08-10, 2016 Birmingham, UK; 8th International Conference on Proteomics, March 20-22, 2017 Philadelphia, USA; 2nd International Conference on Transcriptomics, September 12-14, 2016 Philadelphia USA; 2nd International Conference on Genetic Engineering, November 14-16, 2016 Atlanta, USA; International Conference on Amino Acids and Proteins, December 08-09, 2016 Dallas, USA ; Keystone Symposia Conference on Non coding RNAs in Health and Disease, February 21-24, 2016 Santa Fe, USA; Keystone Symposia on Molecular and Cellular Biology Small RNA Silencing: Little Guides, Big Biology (A6), January 24-28, 2016 Keystone Resort Conference Center, Bošković; Institute Conference on Game of Epigenomics, April 24-26, 2016 Dubrovnik, Croatia; 2016 Conference on RNA 2016, Kyoto, Japan; Abcam Conference on Chromatin, Non-Coding RNAs and RNAP II Regulation in Development and Disease, Mar 29, 2016 Austin, USA
Signal transduction at the cellular level refers to the movement of signals from outside the cell to inside. The movement of signals can be simple, like that associated with receptor molecules of the acetylcholine class: receptors that constitute channels which, upon ligand interaction, allow signals to be passed in the form of small ion movement, either into or out of the cell. These ion movements result in changes in the electrical potential of the cells that, in turn, propagates the signal along the cell. Protein phosphorylation is a fundamental regulatory mechanism that affects nearly every aspect of cellular behaviour. G proteins integrate a multitude of cellular responses, acting as mediators of signalling by many different extracellular compounds.
- Protein phosphorylation networks
- G-proteins in cellular regulation
- Mechanisms of signaling specificity in cell fate: Growth, proliferation or death?
- Transcription mechanisms
- Mechanisms and control of replication initiation
- Mchanisms of genomic stability