Methods of Toxicity Testing

Toxicity testing of new compounds is essential for drug development process. The preclinical toxicity testing on various biological systems reveals the species-, organ- and dose- specific toxic effects of an investigational product. There are distinct types of toxicological analyses that are conducted for different purposes. They include forensic toxicological analysis, workplace drug testing, clinical analysis or hospital drug testing. A toxicity test, by extension, is designed to generate data concerning the adverse effects of a substance on human or animal health, or the environment. Most of the toxicity tests examine specific types of adverse effects, known as endpoints, such as eye irritation or cancer. Other tests are more general in nature, ranging from acute (single-exposure) studies to repeat dose (multiple-exposure) studies, in which animals are administered daily doses of a test substances.

Toxicity testing is necessary to provide some basis for the regulation of substances that humans and other living things may encounter with, intentionally or not. It is used to determine the safety of cosmetics, pharmaceuticals, food additives., pesticides, chemicals, additives and consumer products. Toxicity testing is paramount in the screening of newly developed drugs before it can be used on humans. The essence of toxicity testing is not just to check how safe a test substance is; but to characterize the possible toxic effects it can produce.

  • In vitro toxicity testing
  • In vivo toxicity testing
  • In vivo toxicity testing
  • Carcinogenicity
  • Mutagenicity
  • Hyper Sensitivity tests
  • Acute Toxicity Studies
  • Toxicology screening
  • Ocular and Shin Irritation tests
  • Developmental Toxicity tests
  • Phototoxicity Tests
  • Forensic toxicological analysis
  • Behavioral Tests
  • LD50 test

Methods of Toxicity Testing Conference Speakers