Molecular Farming

The commonly used term ‘molecular farming’ describes the large‐scale production of valuable proteins in transgenic plants, including antibodies, vaccines, other pharmaceuticals and industrial proteins. Compared to traditionally used systems such as microbial cultures, plants offer many advantages with respect to economy, quality and safety. The organism or material into which the new genetic information is inserted is often referred to as the expression system since it serves as the system for “expressing” the new product. Plant molecular farming is currently being pursued to address either the increased demand for proteins that cannot be produced in sufficient quantities in either microbial or animal cell cultures, or as a means to produce proteins that cannot be expressed in microbial or animal cell cultures. Vaccines are another area of research in molecular farming. Early-stage clinical trials have been completed on customized, patient-specific vaccines for Non-Hodgkins Lymphoma. These plant-produced vaccines can be generated in 6 to 10 weeks, a much shorter time frame than conventional methods These plant-produced vaccines can be generated in 6 to 10 weeks, a much shorter time frame than conventional methods. As mentioned previously, edible vaccines, although enthusiastically discussed in recent years, have virtually been abandoned.

The benefits of molecular farming have been demonstrated over the last 15 years through the sustained efforts of a growing number of European research groups, many of which have participated in the COST action “Molecular farming: plants as a production platform for high value protein

Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are engineered to produce recombinant pharmaceutical and industrial proteins in large quantities. As an emerging subdivision of the biopharmaceutical industry, PMF is still trying to gain comparable social acceptance as the already established production systems that produce these high valued proteins in microbial, yeast, or mammalian expression systems. The products of pharming are recombinant proteins or their metabolic products. Recombinant proteins are most commonly produced using bacteria or yeast in a bioreactor, but pharming offers the advantage to the producer that it does not require expensive infrastructure, and production capacity can be quickly scaled to meet demand, at greatly reduced cost.

  • Scope of molecular farming
  • Production of Industrial enzymes and biodegradable plastics
  • Production of antibodies
  • Metabolic engineering for production of fatty acids, Industrial oils, Terpenoids and flavonoids
  • Growth and production kinetics of cell culture in shake flasks

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