Molecularly Targeted Trials: Comparative Approach

Molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, others being hormonal therapy and cytotoxic chemotherapy. As a form of molecular medicine, targeted therapy blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth, rather than by simply interfering with all rapidly dividing cells. Because most agents for targeted therapy are biopharmaceuticals, the term biologic therapy is sometimes synonymous with targeted therapy when used in the context of cancer therapy (and thus distinguished from chemotherapy, that is, cytotoxic therapy). However, the modalities can be combined, antibody-drug conjugates combine biologic and cytotoxic mechanisms into one targeted therapy. Here are some targeted trials done so far for breast cancer, multiple myeloma, lymphoma, prostate cancer, melanoma and other cancers.
  • Tyrosin kinases as an activator of anti-apoptotic Ras signalling cascade
  • Platinum based cancer therapy
  • In vivo molecular target assessment
  • Effect of mutation in protein tyrosine phosphatase gene
  • Protein EZH2 leading to progression of prostate cancer
  • Protooncogene bcl-2 expression in the prostate cancer
  • α-Synuclein Gene mutation leading to Parkinson disease
  • Tau protein as a therapeutic target in Alzheimer disease
  • Stent thrombosis in randomized clinical trials

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