Natural Products as Anti-Cancer Drugs

Dietary sources of natural products are assumed to have anti-cancer benefits include fruits, vegetables and spices yielding biologically active components such as curcumin, resveratrol, cucurbitacins, isoflavones, saponins, phytosterols, lycopene, and many others. A number of these are gaining importance as adjuvant anti-cancer agents with curcumin, resveratrol and cucurbitacins having activity reported against cancer stem cells.  39 natural compounds from marine species, mostly invertebrates, and 10 from microorganisms, mostly from bacteria of the Streptomyces genus, as potential new anti-cancer agents. It is assumed that many prokaryotic and eukaryotic natural product sources may still reveal a number of valuable anti-cancer compounds in the future and even ancient animal species have been suggested as a particularly valuable source.

Cancer is a well-recognized global health problem responsible for 7.6 million deaths (13% of all deaths) worldwide, which is expected to rise to 13.1 million by 2030 Despite the progress in the field of cancer research, both developing and developed countries are in the grip of this deadly disease, and still there is a need to discover and develop anti-cancer therapeutic agents. It has long been recognized that natural products represent the richest source of high chemical diversity, providing the basis for identification of novel scaffold structures that serves as starting points for rational drug design. This can be one of the reasons that efforts have been directed to discover promising cancer therapeutic agents from natural sources. Over the years, many natural product-based drugs have been introduced in the market. According to a recent review, 49% of drugs were either natural products or their derivatives that are used in cancer treatment. Moreover, between the year 2005 and 2010, 19 natural product-based drugs have been approved, among which 7, 10 and 2 have been classified as natural product (NP), semi-synthetic NPs and NP-derived drugs, respectively. Of these, five drugs, temsirolimus, trabectedin, ixabepilone, everolimus and romidepsin, have been developed in the area of oncology from 2007 to 2009. Indeed, it has been suggested that less than one-fifth of the ring systems found in natural products are represented in current trade drugs 

The plant based drug discovery resulted mainly in the development of anticancer agents including plants (vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan and irinotecan), marine organisms (citarabine, aplidine and dolastatin 10) and micro-organisms (dactinomycin, bleomycin and doxorubicin). Beside this there is numerous agents identified from fruits and vegetables can used in anticancer therapy. Plants have a long history of use in the treatment of cancer and it is significant that over 60% of currently used anti-cancer agents are come from natural sources. Nature is an attractive source of new therapeutic candidate compounds as a tremendous chemical diversity is found in millions of species of plants, animals, marine organisms and microorganisms as potential anti-cancer agent.

  • Marine organisms having antineoplastic activity
  • Potent alkaloidal neurotoxins
  • Polyketide neurotoxins
  • Preclinical anticancer lead compounds
  • Multitude of mixed biogenesis metabolites
  • In vitro and in vivo anticancer and antioxidant assays

Related Conference of Natural Products as Anti-Cancer Drugs

August 26-27, 2020

33rd World Congress on Pharmacology

Barcelona, Spain
August 26-26, 2020

pharmaceutics and drug discovery

London, UK
August 31-01, 2020

13th European Biosimilars Congress 2020

London, UK
September 07-08, 2020

Global Summit on Generic Drugs and Quality Control

Prague, Czech Republic
September 09-10, 2020

World Pharma Expo

Amsterdam, Netherlands
September 10-11, 2020

World Congress on Rare Diseases & Orphan Drugs

Prague, Czech Republic
September 14-15, 2020

16th Annual Congress on Pharmacology and Toxicology

Vienna, Austria
September 16-17, 2020

Global Pharmacovigilance And Clinical Trials Summit

Shanghai, China
September 18-19, 2020

International Conference on Pharmaceutical Chemistry

Dubai, UAE
September 21-22, 2020

35th World Pharmacology and Toxicology Forum

Tokyo, Japan
September 22-23, 2020

6th Annual Congress on Clinical & Hospital Pharmacy

Singapore City, Singapore
September 24-25, 2020

20th World Congress on Advances in Pharmaceutical Sciences

Singapore, Singapore
October 05-06, 2020

International Congress on Drug Delivery

Auckland, Newzealand
October 15-16, 2020

nanomedicine-pharma-2020

Rome, Italy
October 21-22, 2020

20th Annual Meet on Pharmaceutical Sciences

Bangkok, Thailand
October 21-22, 2020

27th World Congress on Pharmacovigilance and Clinical Trials

Frankfurt, Germany
October 26-27, 2020

22nd International Conference on Drug Design and Development

Amsterdam, Netherlands
November 09-10, 2020

2nd World Congress on Drug Discovery and Drug Design

Tokyo, Japan
November 09-10, 2020

21st Global Summit on Analytical and Bioanlaytical Techniques

Amsterdam, Netherlands
November 9-10, 2020

Annual Meet on Pharmacovigilance & Drug Safety

Tokyo, Japan
November 09-10, 2020

20th Medicinal & Pharmaceutical Sciences Congress

Budapest, Hungary
November 09-10 , 2020

Asia Pacific Pharmaceutics & Drug Delivery Congress

| Tokyo , Japan
November 11-12, 2020

4th World Congress on Eye and Vision

Dubai, UAE
November 16-17, 2020

World Congress on Biologics and Biosimilars

Kyoto, Japan
November 19-20, 2020

Global summit on Cosmetic and Reconstructive Surgery

Tokyo, Japan
November 23-24, 2020

Pharma Expo China

Paris, France
November 23-24, 2020

Pharmaceutics & Novel Drug Delivery Summit China

Paris, France
November 23-24, 2020

21st Middle East PharmaTech & Expo

Istanbul, Turkey
November 25-26, 2020

8th World Congress on Antibiotics, Antimicrobials & Antibiotic Resistance

Singapore City, Singapore
November 26-27, 2020

11th World Congress on Bioavailability and Bioequivalence

Istanbul, Turkey
December 02-03, 2020

2nd International Conference on Bio-Pharmaceuticals

Auckland, Newzealand
December 07-08, 2020

International Liver Congress

Dubai, UAE
December 07-08, 2020

International Conference on Biotechnology and Healthcare

Auckland, Newzealand
May 11-12, 2021

6th Pharmaceutical Chemistry Conference

Paris, France
May 18-19, 2021

8th European Biopharma Congress

Prague, Czech Republic

Natural Products as Anti-Cancer Drugs Conference Speakers

Recommended Sessions

Related Journals

Are you interested in