Neural regulation

The central nervous system (CNS) regulates innate immune responses through hormonal and neuronal routes. The neuroendocrine stress response and the sympathetic and parasympathetic nervous systems generally inhibit innate immune responses at systemic and regional levels, whereas the peripheral nervous system tends to amplify local innate immune responses. These systems work together to first activate and amplify local inflammatory responses that contain or eliminate invading pathogens, and subsequently to terminate inflammation and restore host homeostasis. Here, I review these regulatory mechanisms and discuss the evidence indicating that the CNS can be considered as integral to acute-phase inflammatory responses to pathogens as the innate immune system.

The innate immune response to infectious and sterile injury is modulated by neural circuits that control cytokine production period. The Inflammatory Reflex is a prototypical neural circuit that controls cytokine production in spleen.  Action potentials transmitted via the vagus nerve to spleen mediate the release of acetylcholine, the neurotransmitter that inhibits cytokine release by interacting with alpha7 nicotinic acetylcholine receptors (CHRNA7) expressed on cytokine-producing cells. The motor arc of the inflammatory reflex is termed the cholinergic anti-inflammatory pathway.

  • cholinergic anti-inflammatory pathway.
  • Immune cell trafficking

Related Conference of Neural regulation

October 19-20, 2018

10th World Congress and Expo on Immunology

New York, USA
October 29-30, 2018

6th International Conference on HIV/AIDS, STDs and STIs

San Francisco, USA
November 26-27, 2018

3rd International Conference on Autoimmunity

Dublin, Ireland (Louis Fitzgerald Hotel)
December 05-06, 2018 | Lisbon, Portugal

Global Meet onImmunology, Hematology & Molecular Biology

Holiday Inn Lisbon - Continental, R. Laura Alves 9, 1069-169 Lisboa, Portugal
December 06-08, 2018

Annual Congress on Antibiotics and Antimicrobial Resistance

Amsterdam, Netherlands
February 22-23, 2019

World Congress on Immunity and Immuno Therapies

Dallas, Texas, USA
March 04-05, 2019

10th Molecular Immunology & Immunogenetics Congress

Barcelona, Spain
March 17-18, 2019

International Congress on Autoimmunity

Brisbane, Australia
March 18-19, 2019

11th Global Summit on Immunology and Cell Biology

Sydney, Australia
June 13-14, 2019 |

10th European Immunology Conference

Berlin, Germany
July 19-20, 2019

8th International Conference on Clinical Trials

| Atlanta, USA
October 21-22, 2019

12th Annual Congress on Immunology & Immunogenetics

Rome, Italy
November 22-23, 2019 |

World Conference on Vaccine and Immunology

Dubai, UAE

Neural regulation Conference Speakers

Recommended Sessions

Related Journals

Are you interested in