Neuro virology

The study of the viruses which infect nervous system is called Neuro virology. Viral infections of brain are a bit complicated to understand due to the various underlying reasons. One of the main reasons is that the virus acts in an unpredictable manner due to this much of the experiments carried out are based on testing the hypothesis which is a major drawback.

Viral infections of the brain are less common than any other infections because unlike other organ infections brain infections depend upon the breakdown and passage through the blood brain barrier which occurs very rarely. Viruses take advantage of such events and cause neurological problems through a number of mechanisms like causing cell lysis, inducing apoptosis or by creating secondary damage due to release of glutamate. Viruses such as rabies do not kill neurons but they alter cellular transcriptional pathways to express viral genes rather than neuronal genes, these results in neurons that no longer function as neurons, but look normal upon routine pathological examination making it difficult for the virologist to identify the virus. Due to all these reasons we need to have a complete understanding and knowledge of viruses and their makeup in order to identify and treat that infection.

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