Pathogenesis and Immunity

Resistance to parasitic worms/protozoa appears to be similar to resistance against other infectious agents, although the mechanisms of resistance in protozoan infections are not yet as well understood. Resistance can be divided into two main groups of mechanisms: (1) nonspecific mechanism(s) or factor(s) such as the presence of a nonspecific serum component that is lethal to the parasite; and (2) specific mechanism(s) involving the immune system. Probably the best studied nonspecific mechanisms involved in parasite resistance are the ones that control the susceptibility of red blood cells to invasion or growth of plasmodia, the agents of malaria. 

  • Microbial Adherence
  • Invasion of Host cells and Intracellular Survival
  • Evasion of Immune Responses
  • Microbial Toxins
  • Viral Replication and Transformation
  • Oncogene expression
  • Intracellular Signaling
  • Host Genetic Factors

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