Pharmacogenetics

Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. The term Pharmacogenetics is regularly utilized reciprocally with the term pharmacogenomics which additionally explores the part of procured and acquired hereditary contrasts in connection to medicate reaction and medication conduct through an efficient examination of qualities, quality items, and between and intra-singular variety in quality articulation and capacity. In oncology, Pharmacogenetics truly is the investigation of germ line transformations (e.g. single-nucleotide polymorphisms influencing qualities coding for liver catalysts in charge of medication testimony and pharmacokinetics), though pharmacogenomics alludes to physical changes in tumoral DNA prompting adjustment in tranquilize reaction (e.g. KRAS transformations in patients treated with hostile to Her1 biologics).

  • Candidate genes/regions and fine mapping
  • Functional studies of associated variants or loci
  • Genome-wide association studies
  • Implementation of individualized medicine
  • Sequencing studies/rare variants

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