Pharmacogenomics: Convergence of Pharmacology & Genomics

In pharmacogenomics, genomic information is used to study individual responses to drugs. When a gene variant is associated with a particular drug response in a patient, there is the potential for making clinical decisions based on genetics by adjusting the dosage or choosing a different drug, for example. Scientists assess gene variants affecting an individual's drug response the same way they assess gene variants associated with diseases: by identifying genetic loci associated with known drug responses, and then testing individuals whose response is unknown. Modern approaches include multigene analysis or whole-genome single nucleotide polymorphism (SNP) profiles, and these approaches are just coming into clinical use for drug discovery and development. 

  • Drug Safety
  • Genotype, Phenotype, and ADRs
  • Improving Cancer Outcomes
  • Therapeutic Promise of the Human Genome Project

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