Probioceuticals: Probiotic- Derived Factors

Probiotic-derived factors have been described as capable of exerting probiotic activities through various mechanisms. However, it is important to distinguish between the concept of probiotic, which is necessarily based on the ingestion of live microorganisms, and the concept of microorganism-derived bioactive compounds that may have useful applications in nutrition and medicine. Bioactive compounds of bacterial or yeast origin, (antibiotics, for example), have been utilized in medicine for decades. Although there are many bacteria-derived products capable of inducing a health benefit, the concept of probiotic is only attributed to microorganisms administered as viable forms, providing the opportunity for a symbiotic relationship between the host, and resident, or in-transit, microorganisms. Secreted probiotic factors, such as reuterin from Lactobacillus reuteri, have been reported to inhibit adhesion and viability of known enteric pathogens, suggesting that probiotic supernatants could be a rich source of new antipathogenic compounds. In an in vitro study in human gastric epithelial cells, spent culture supernatants from certain lactic acid producing bacteria inhibited the growth and attachment of Helicobacter pylori. Roselli et al. demonstrated that supernatants of Bifidobacterium animalis MB5 and Lactobacillus GG could inhibit adhesion of E. coli K88 to Caco-2 cells, with the supernatant exerting identical beneficial effects following protease digestion, suggesting that proteins were not the active constituent.

  • Stress Management
  • Collagen generation
  • Cartilage protection as well as regeneration
  • Clinical efficacy to support GI and Immune health
  • Supports liver, cardiovascular and kidney health

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