Protein Engineering & Molecular Design

Protein engineering is the process of developing useful or valuable proteins. It is a young discipline, with much research taking place into the understanding of protein folding and recognition for protein design principles. It is also a product and services market, with an estimated value of $168 billion by 2017. There are two general strategies for protein engineering, 'rational' protein design and directed evolution. These techniques are not mutually exclusive; researchers will often apply both. In the future, more detailed knowledge of protein structure and function, as well as advancements in high-throughput technology, may greatly expand the capabilities of protein engineering. Eventually, even unnatural amino acids may be incorporated, thanks to a new method that allows the inclusion of novel amino acids in the genetic code.

Structure-based drug discovery is central to the efficient development of therapeutic agents and to the understanding of metabolic processes. The traditional way of drug discovery is the experimental screening of large libraries of chemicals against a biological target (high-throughput screening or HTS) for identifying new lead compounds.

  • Genetic, enzyme & antibody engineering
  • Therapeutic protein analysis
  • Protein arrays, biochips and proteomics
  • Protein-protein interactions
  • Protein phosphatases & folding in the cell
  • Genetic function approximation to QSAR
  • Molecular dynamics & mechanics
  • Molecular docking studies
  • Chemistry on drug discovery
  • Targeted drug delivery and gene therapy

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