Rare Skin Diseases

 Most of the diseases influences the skin begin within the layers of the skin, such abnormalities are also important factors in the diagnosis of a variety of internal diseases. The skin has an inherent region-specific anatomical diversity which will profoundly modify the appearance of a rash. This is apparent when skin transplanted from one area of the body to another retains the morphological characteristics of the donor area. The classification of hereditary skin disorders generally has been based upon gross morphological, histological and electron microscopic findings; however, because a skin disease may not always have a characteristic presentation, the specific diagnosis sometimes has been in doubt. For example Aarskog syndrome is an inherited disease that affects a person's height, muscles, skeleton, genitals, and appearance of the face.[ Making a diagnosis for a rare or genetic disease can often be challenging. 

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