Rheumatic Diseases

A study found that childhood obesity was significantly associated with adult knee pain in men and childhood weight and body mass index (BMI) were associated with stiffness and dysfunction. Subjects who were overweight in both childhood and adult life had a significant increase in the adulthood walking knee pain compared with those who had normal weight in both childhood and adult life. These associations were most notable in males. These indicate the importance of reducing childhood obesity in preventing adulthood knee symptoms.

The growing body of evidence recognizing the adipose tissue (AT) as an active endocrine organ secreting bioactive mediators involved in metabolic and inflammatory disorders, together with the global epidemic of overweight and obesity, rise obesity as a hot topic of current research. The chronic state of low-grade inflammation present in the obese condition and the multiple pleiotropic effects of adipokines on the immune system have been implicated in the pathogenesis of several inflammatory conditions including rheumatic autoimmune and inflammatory diseases.

  • Obesity Linked to Osteocalcin
  • Effect of Obesity on Rheumatoid Arthritis
  • Impact of Excess Weight on Orthopaedic Problems
  • Obesity & Infantile Blount Disease

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