Separation techniques in pharmaceutical chemistry

The development of the pharmaceuticals brought a revolution in human health. These pharmaceuticals would serve their intent only if they are free from impurities and are administered in an appropriate amount. To make drugs serve their purpose various chemical and instrumental methods were developed at regular intervals which are involved in the estimation of drugs. These pharmaceuticals may develop impurities at various stages of their development, transportation and storage which makes the pharmaceutical risky to be administered thus they must be detected and quantitated. For this analytical instrumentation and methods play an important role.


  • Fluorimetry and phosphorimetry
  • Near -infrared spectroscopy (NIRS)
  • Electrochemical methods
  • Electrophoretic methods
  • Flow injection and sequential injection analysis
  • Pharmacovigilance
  • Titrimetric techniques
  • Nuclear magnetic resonance spectroscopy (NMR)
  • Kinetic method of analysis
  • High performance thin layer chromatography

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