Signaling Defects and Diseases

Ample number of diseases is caused by defects in signaling pathways. The nature of these defects and how they are induced varies excessively. Pathogenic organisms and viruses, many of which can obstruct with signaling events, cause some of these defects. The thought of signalsome remodeling and disease provides a schema for considering how defects in signaling pathways can conclude in disease. Most of the severe diseases in humans, such as hypertension, diabetes and many forms of mental illness, look to appear from subtle phenotypic modifications of signaling pathways. 

Genotypic modifications culminating from either somatic mutations or germline mutations have been somewhat simpler to diagnose, but have also proved difficult to treat by the failure of many of the gene therapy strategies. Precisely, there is an crucial demand to understand more about all of these disease states in order to design improved therapies. The huge redundancy assembled into cell signaling mechanisms hit many opportunities for discovering advanced approach of correcting many disease states. The reversal of Ca2+-dependent neurodegeneration is a case in which this type of strategy could provide novel therapies for treating some of the major neural diseases in humans such as Alzheimer's disease and Parkinson's disease.

  • Pathogenic organism and viruses related disease in cell signaling
  • Phenotypic and genotypic remodeling of the signalsome
  • Cell proliferation and cell differentiation related disease
  • Advancements in cell signaling technologies

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