Stem Cell Technology in Breast Cancer

The normal stem cell microenvironment or “niche” comprises a discrete dynamic domain within a tissue, with the ability to ensure tissue homeostasis under physiological and pathological conditions. It prevents the differentiation of stem cells and coordinates their behaviour in homeostasis and repair. The deregulation of genetic homeostasis of the stroma can promote tumorigenesis. It is yet unclear whether in neoplastic tissues CSCs utilize and modulate their existing microenvironment or direct the formation of a new niche. Many soluble factors of the cancer microenvironment are involved in the maintenance of the CSC phenotype within a cancer.

 

  • circulating cancer cells
  • targeting cancer stem cells
  • stem cell technology

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