Tolerance of Autoimmunity

Immunological tolerance describes a state of unresponsiveness of the immune system to substances or tissue that has the capacity to elicit an immune response. It contrasts with conventional immune-mediated elimination of foreign antigens. Tolerance is classified into central tolerance or peripheral tolerance. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities. Deficits in central or peripheral tolerance also cause autoimmune disease, Tolerance, however, also has its negative tradeoffs. It allows for some pathogenic microbes to successfully infect a host and avoid elimination.In addition, inducing peripheral tolerance in the local microenvironment is a common survival strategy for a number of tumors that prevents their elimination by the host immune system.

Immunological tolerance is an individual that presence of autoimmune syndrome which has unexplained infertility, endometriosis, and repetitive miscarriages due to elevated levels of antinuclear antibodies circulating. Both the presence of anti-phospholipids antibodies and antinuclear antibodies has toxic effects on the implantation of embryos and Autoimmunity Tolerence accure in the body.

  • Self Antigens Tolerance
  • Drugs Tolerance
  • Soluble Antigen Tolerance
  • Tissues and Cells Tolerance
  • Non- Self Antigens Tolerance

Related Conference of Tolerance of Autoimmunity

Tolerance of Autoimmunity Conference Speakers