Transparent animal model for Neuroimaging

Track 20: Transparent animal model for Neuroimaging

 To understand the causes of mental health conditions and functioning of the brain in neurological disorders like Cerebral ischemia, Epilepsy, Traumatic brain injury, Parkinson's disease, Huntington's disease, Multiple sclerosis, Acute CNS inflammation, animal models are used. The example of animals used are Baboon (Papio papio), mouse (DBA/2J), genetically epilepsy-prone rats (GEPRs), rabbits, and the Fayoumi chicken, rat. Improved imaging techniques allow the gross structure and function of the brain to be assessed in vivo, the organ cannot be biopsied for detailed analysis; samples of brain tissue that can be obtained are often affected by post mortem perseveration processes and/or by factors including drug treatment, trauma, infectious disease or seizures. These combined challenges explain why effective new drugs for treating psychiatric disorders have not been forthcoming, and why we continue to rely on medications which often have limited efficacy or undesirable side-effects.

Animal models for Alzheimer’s disease it is important to think about the human phenotype and what is being modeled in terms of the animal phenotype. Even though the anatomy in the mouse is different than the human, mutant tau mice are relatively good models in that they recapitulate tau-dependent neurodegeneration. Although these are incomplete models of the human disease, they have been well received in the field as potentially relevant models for use in drug discovery.

The models include                                         

·        Transgenic models

·        Pharmacological and lesion models

·        Natural and seminatural models

·        Primate models

·        Zebra fish models

·        Animal models of human cognitive aging

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