Upstream Bioprocessing

The Upstream process is defined as the entire process from early cell isolation and cultivation, to cell banking and culture expansion of the cells until final harvest (termination of the culture and collection of the live cell batch). Upstream Bioprocessing involves Cell therapy research, Drug discovery, Preventing cell line cross contamination, Overcoming challenges in Bioprocess engineering, Nucleic acid and protein sample preparation, Stem cell research, Upstream and downstream for therapeutic antibody production & recombinant production, Upstream Single-use technologies. 29 universities offering Cell processing in USA. 194 universities offering from other part of the world. 10, 000, 00 $ funds are released in USA for year 2014. In other part of the world $ 1 crore were released in 2014. There are 25000 more industries working on Upstream Bioprocessing.

Therapeutic cell manufacturing processes can be separated into upstream processes and downstream processes. The upstream process is defined as the entire process from early cell isolation and cultivation, to cell banking and culture expansion of the cells until final harvest (termination of the culture and collection of the live cell batch).

Aside from technology challenges, concerning the scalability of culture apparatus, a number of raw material supply risks have emerged in recent years, including the availability of GMP grade fetal bovine serum. This is discussed in the seminal piece: "Peak Serum: Implications for Cell Therapy Manufacturing. The upstream part of a bioprocess refers to the first step in which microbes or cells are grown, e.g. bacterial or mammalian cell lines, in bioreactors. Upstream processing involves all the steps related with inoculum development, media development, improvement of inoculum by genetic engineering process, optimization of growth kinetics so that product development can improve tremendously. Fermentation has two parts: upstream and downstream. After product development, the next step is purification of product for desired quality. When they reach the desired density (for batch and fed batch cultures) they are harvested and moved to the downstream section of the bioprocess.  Upstream bioprocessing includes Cell therapy research, Drug discovery, Preventing cell line cross contamination, Overcoming challenges in Bioprocess engineering, Nucliec acid and protein sample preparation, Upstream and downstream for therapeutic antibody production & recombinant production, Upstream Single-use technologies.

  • Cell therapy research
  • Drug discovery
  • Preventing cell line cross contamination
  • Overcoming challenges in Bioprocess engineering
  • Nucliec acid and protein sample preparation
  • Upstream and downstream for therapeutic antibody production & recombinant production
  • Upstream Single-use technologies

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