Vaccines against Vector-borne Diseases

Vaccines that target blood-feeding disease vectors, such as mosquitoes and ticks, have the potential to protect against the many diseases caused by vector-borne pathogens. Vector-borne diseases are among the most complex of all infectious diseases to prevent and control. Vector- borne diseases, most of which are transmitted in and around the home, are best controlled by a combination of vector control (use of public health insecticides on bednets, or by spraying), medicines and vaccines.

Historically, successful vector-borne disease prevention resulted from management or elimination of vector populations.  Malaria was driven out of the USA and most of Europe in this way. Where vector control has been consistently applied in the past, the results have been dramatic, especially with early efforts to control malaria by spraying the inside surfaces of houses with insecticides. Indoor Residual Spraying (IRS) and long-lasting insecticide treated bednets have been very effective over the last 10 years and are widely regarded as one of the main contributors to the more than 1 million lives saved.

In contrast to expenditure and effort on medicine, diagnostic and vaccine development, relatively little attention was given to vector control in the past.  The foresighted establishment of IVCC in 2005, with a grant from the Bill and Melinda Gates Foundation began the process of bringing Vector Control into the mainstream strategy for future eradication of malaria and other vector-borne diseases.

  • Zika Virus
  • Malaria
  • Dengue
  • Chikungunya
  • Yellow fever
  • Lyme disease
  • Japanese encephalitis
  • Leishmaniasis

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