Vaccines, Drug Development and Control Measures

Currently disease control and treatment of parasitic infections focuses on chemotherapy, but re-infection often occurs without continued treatment, making vaccination a far preferable option as a simple, one-step procedure to interrupt transmission. Many advances are under way in parasite genomics, as well as new vaccine delivery systems. Malaria is a subversive, ignored, yet common cause of death throughout the world. It causes over one million deaths per year, making it one of the greatest silent killers of humans. However, there are certain steps that can be taken to control its endemicity. Unlike some infectious diseases whose frequency are declining, due to prevention efforts and scientific advances in treatment and vaccines, malaria prevalence continues to rise due to wide-spread resistance to many of the current drugs. There are no successful malaria vaccines. Hence, there is an emerging need for scientific research in these fields for the well-being of mankind.

Significant effort and progress has occurred over the last several years in the development of vaccines against three main tropical parasitic diseases. However, an effective vaccine is not yet available. The difficulties in developing a vaccine against parasitic disease are complicated not only by the necessity to identify and produce appropriate, protective antigens but also a lack of complete understanding of the types of immune responses needed for protection. Despite these hurdles, several candidate vaccines are under development for each disease; at least one promising vaccine candidate exists that is in late stage clinical testing.

  • Malaria Vaccine
  • Hookworm Vaccine
  • Schistosome Vaccine
  • Anti-Parasitic Drug Development
  • Immunocompromised Host
  • Mosquito control
  • Anti-Malarial Drug Development

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