|A cold-induced inflammatory mechanism gradually reduced fat thickness in 90 days after a 30- to 60 minute cold plate exposure to the skin surface. In vitro examination of the adipocytesâ response to cold showed that the cooling of adipocytes to temperatures above freezing but below normal body temperature resulted in apoptosis â mediated cell death, which suggested that cryolipolysis produced an apoptotic injury in the adipose tissue. Furthermore, the subsequent inflammatory response may cause additional damage to those adipocytes not immediately affected by the cold exposure
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