alexa Designer Immunotherapy Specific for Cancer | OMICS International
ISSN: 2157-7013
Journal of Cell Science & Therapy

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Designer Immunotherapy Specific for Cancer

Shengwen Calvin Li* and Mustafa H Kabeer*
CHOC Children’s Hospital, University of California Irvine, Orange, CA 92868, USA
Corresponding Authors : Shengwen Calvin Li
CHOC Children’s Hospital
University of California Irvine
Orange, CA 92868, USA
E-mail: [email protected]
  CHOC Children’s Hospital
University of California Irvine
Orange, CA 92868, USA
E-mail: [email protected]
Received January 16, 2013; Accepted January 16, 2013; Published January 18, 2013
Citation: Li SC, Kabeer MH (2013) Designer Immunotherapy Specific for Cancer. J Cell Sci Ther 4:e116. doi: 10.4172/2157-7013.1000e116
Copyright: © 2013 Li SC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Cell Science & Therapy

In the USA, cancer affected over 1.4 million people in 2007 and we spent over $206 billion, one third of the total healthcare expenditure of $686 billion, to develop cancer therapies (NCI). Much is known about gene mutations and yet this has not been successfully translated into meaningful therapy for cancer patients. This unmet need urgently demands for new therapies to be developed. A promising subset of cancer therapy is immunotherapy. Cancer immunotherapy aims at inducing, enhancing, or suppressing an immune response to reject and destroy tumors.
Cancer immunotherapeutic agents include immunomodulors (often cytokines [1] or chemokines) and immune effector cells (lymphocytes, macrophages, dendritic cells, natural killer cells (NK Cell), cytotoxic T lymphocytes (CTL), etc.). Many forms of these therapeutic strategies have showed efficacy in animal models; unfortunately, they did not translate well during human clinical trials. Surprisingly, a recent report showed that immune T-cell therapy for the treatment of chronic lymphocytic leukemia (CLL) works better in humans than it does in mice ( number NCT01029366) [2]. It shed new light on the treatment of CLL, a highly lethal disease. What made it succeed?
In this study, June et al. address the issue of the horrendous side effects of conventional cancer therapy utilizing techniques such as bone marrow transplantation to treat CLL. Many patients developed graft-versus-host disease upon undergoing allogeneic hematopoietic stem cell transplantation and still faced a high relapse rate with limited chances for cure [3]. June’s group developed a technology to create gene-modified T cells that do not cause graft versus host disease and target malignant CLL cancer cells with high specificity [2].
This technology uses a patient’s own T cells subjected to the designer engineering specific for killing CLL cancer cells. They engineered T-cells expressing CD19-specific chimeric antigen receptor (CART-19) [4]. The designer T-cells recognize CD19 antigen on the surface of cells such as non-Hodgkin’s lymphoma, acute lymphoblastic leukemia, and chronic lymphocytic leukemia. This modification enables the designer T cells to recognize the cancer and become activated thus triggering tumoricidal activity. In the clinical trial on leukemia patients, each patient had between 3 to 7 pounds of tumor burden that was eradicated by these designer T cells. The first treated patients remain leukemia-free for more than three years. Potential drawbacks remain to be determined since the T-cell targeted CD19 is not only expressed by cancer cells but also by normal B cells. CD19 is not expressed by hematopoietic stem cells or other tissues.
In principle, this concept may be expanded to a wide spectrum of other human cancers [5]. CART-19 used in June’s study, is a chimeric molecule that has both the binding domain of an antibody on the cell surface as well as the T cell receptor complex and costimulating signaling modules within the cell [2]. This modular construction allows for changing the antibody binding domain, allowing these engineered T cells to recognize molecules on other types of cancer cells, such as CD3-specific single-chain antibody fragment (scFv) [6,7]. PDL1 [8], NY-ESO-1 and LAGE-16, or mesothelin in prostate and breast cancers [5,9]. Indeed, June’s group has tested this idea for treating pancreatic cancer as well with optimistic but preliminarily results [7]. The longterm benefit of this platform providing clinical translation of promising advances in immunotherapy remains to be seen by clinical trials monitoring outcomes of patients with other types of cancer.
Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 11997
  • [From(publication date):
    July-2013 - Aug 19, 2018]
  • Breakdown by view type
  • HTML page views : 8218
  • PDF downloads : 3779

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037


James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals


Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T


[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version