|Drug disposition is the knowledge about the fate of a drug such as its absorption, distribution, metabolism, and excretion, known by the acronym ADME and its pharmacokinetics. The pharmacokinetics describes the rates of these processes and of concentration-time relationships. In preclinical and early clinical drug development, information about the factors influencing drug disposition used to predict drug interaction potential, estimate and understand population pharmacokinetic variability, and select doses for clinical trials.
High-impact journals are those considered to be highly influential in their respective fields. The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.