|Drug disposition is the knowledge about the fate of a drug such as its absorption, distribution, metabolism, and excretion, known by the acronym ADME and its pharmacokinetics. The pharmacokinetics describes the rates of these processes and of concentration-time relationships. In preclinical and early clinical drug development, information about the factors influencing drug disposition used to predict drug interaction potential, estimate and understand population pharmacokinetic variability, and select doses for clinical trials.
A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity. Each such journal article becomes part of the permanent scientific record.