The various novel drug delivery systems of curcumin such as various nanoparticles, micellar formulations, liposomes and cyclodextrin inclusion complexes that have been reported in order to improve the solubility, bioavailability and efficacy of curcumin.Earlier pharmacokinetic studies ofcurcuminhave revealed poor absorption and rapid metabolismthat severely curtails its bioavailability, leading to extremely low serum levels.Eucalyptol curcumin-microemulsionswas found to have high permeability and flux compared to oleic acid and esteem oil-based microemulsions.Other microemulsions such as selfmicroemulsifying drug delivery system (SMEDDS) comprising 20% ethanol, 60% Cremophor RH40Â® and 20% isopropyl myristatehadcurcumin encapsulation efficiency of 50 mg/mL and the drug was entirely released in 10 minutes. This was shown to increase dissolution and bioavailability in vivo.several novel drug delivery strategieshave been described to increase solubility, bioavailability and delivery of curcumin. However, much work is needed to further investigate the pharmacokinetics, enhance the delivery at the target tissues, the bioavailability and medicinal value of curcumin. (Asish K Dutta and Elizabeth Ikiki, Novel Drug Delivery Systems to Improve Bioavailability of Curcumin)
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Last date updated on July, 2014