alexa Ajay Singh | Department of Oncologic Sciences Mitchell
ISSN: 2157-7536

Journal of Steroids & Hormonal Science
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Ajay Singh

Ajay Singh Ajay Singh
Department of Oncologic Sciences
Mitchell Cancer Institute
University of South Alabama
USA

 
Biography

Ajay Singh, Ph.D., is an Assistant Professor of Oncologic Sciences at University of South Alabama Mitchell Cancer Institute (USAMCI). Dr. Singh received a Master’s degree in Biotechnology from Aligarh Muslim University and graduated from the Devi Ahilya University, Indore, India. He completed a short post-doctoral fellowship in the Department of Biochemistry and Molecular Biology at University of Nebraska Medical Center, Omaha, Nebraska. He later attained a research faculty position in the same department, and joined USAMCI in 2009 as a tenure-track faculty. Studies in Dr. Singh’s laboratory have been supported through state and federal grants. He was awarded funds from State of Nebraska for two consecutive years (2007 and 2008) and one grant each from National Cancer Institute (NCI) and Department of Defense (DOD) to support his research. Dr. Singh serves on regional, national and international panels to review research proposals for funding considerations.

Research Interest

Dr. Singh’s research is to delineate the molecular mechanisms underlying the aggressive and therapy-resistant behavior of cancer cells. In particular, his lab is investigating the role of microRNAs and tumor microenvironment in facilitating growth, epithelial to mesenchymal transition (EMT), metastasis and drug-resistance of pancreatic and prostate tumor cells. Earlier studies of Dr. Singh identified a mucin gene, MUC4, to be of pathological significance in pancreatic cancer progression and metastasis. MUC4 is an aberrantly expressed glycoprotein in pancreatic cancer exhibiting no expression in the normal pancreas. Recently, his team identified a novel microRNA-mediated mechanism involved in its deregulation in pancreatic cancer. Dr. Singh’s research has also revealed that CXCL12-CXCR4 signaling axis, an exemplary of tumor-microenvironment interaction, promotes drug-resistance in pancreatic cancer cells. In additional studies, his group has identified protein phosphatase 2A (PP2A) as a novel therapeutic target in prostate cancer. They have shown that PP2A activity is inversely associated with androgen-independent growth of prostate cancer cells through a novel mechanism, whereby loss of PP2A-mediated checkpoints leads to the activation of Akt and ERK and partially sustains androgen receptor signaling under steroid-deprived condition. The findings from Dr. Singh’s lab offer potential therapeutic implications for microRNAs, PP2A and tumor-microenvironment in highly aggressive and therapy-resistant pancreatic and/or prostate malignancies

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Publications

Indian Herb Hemidesmus indicus - A Potential Source of New Antimicrobial Compounds
Zafar Mehmood, Arunesh K Dixit, Ajay Singh, S Farooq and Suman Lata Chhimwal
Research Article: Med chem (Los Angeles) 2016, 6: 734
DOI: 10.4172/2161-0444.1000422
 
Operation Sequencing in CAPP by using Artificial Neural Network
Ajay Singh Rana,Raman Kumar, Mahakdeep Singh, Arun Kumar
Research Article: IJIRSET
 
Comparative Characterization of Foxtail Millet, Physico-Chemical Approach for its Suitability to Celiacs
Ajay Singh and Bahadur S Hathan
Research Article: J Food Process Technol 2014, 5: 382
DOI: 10.4172/2157-7110.1000382
 
Isolation, Identification and Characterization of Unknown Impurity in Fermentation Based Active Pharmaceutical Ingredient Lovastatin.
Chandrakant Belwal, Divyesh Patel, Kamlesh Chauhan, Yogendrasinh Parmar, Ajay Singh Rawat, and Anand Vardhan
Research Article: Pharmaceutical Analysis
 
Lot Quality Assurance Sampling for Monitoring and Evaluation of Immunization Coverage in District Solan, Himachal Pradesh, India, 2011
Ajay Singh and Narasimha Murthy B
Research Article: J Community Med Health Educ 2014, 4:259
DOI: 10.4172/2161-0711.1000259
 
Study of In-Vivo Effects Caused by Metabolites (1,2,4-Trizole Alanine) of Steroid-Inhibitor Fungicide on Aquatic Life (Fish)
Ajay Singh and Pallavi Srivastava
Research Article: J Aquac Res Development
DOI: 10.4172/2155-9546.1000183
 
Large Anterior Lumbar-Sacral Meningocele
Iyengar SN, Avdesh Shukla, Ajay Singh and Sumit Raj
Case Report: J Spine 2013, 2: S2-003
DOI: 10.4172/2165-7939.S2-003
 
Heavy Metal Concentrations in Pharmaceutical Effluents of Industrial Area of Dehradun (Uttarakhand), India
Bharti Ramola and Ajay Singh
Research Article: J Environ Anal Toxicol 2013, 3:173
DOI: 10.4172/2161-0525.1000173
 
Estimation of Nevirapine from Human Plasma by ESI-LC-MS/MS: a Pharmacokinetic Application
Chinmoy Ghosh, Shashank Gaur, Ajay Singh, Chandrakanta P. Shinde and Bhaswat S. Chakraborty
Research Article: JBB/Vol.3.1 020-025 (2011)
DOI: 10.4172/jbb.1000052
 
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