alexa Alistair McGregor | Texas A and M University
ISSN: 2161-0703

Journal of Medical Microbiology & Diagnosis
Open Access

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Alistair McGregor

Alistair McGregor Alistair McGregor
Associate Professor
Dept. of Microbial Pathogenesis & Immunology
Texas A & M University

Dr. McGregor has a broad training in Virology and has worked on RNA and DNA viruses. His Ph.D. studies were on Bunyaviruses and his post-doctoral research was on herpes simplex (HSV) and cytomegalovirus (CMV). He has developed infectious bacterial chromosomes (BACs) of herpesviruses to enable easy manipulation of various viruses (including HSV, HCMV and GPCMV) to study gene function and viral pathogenicity factors. He currently has a funded research program into antiviral and vaccine strategies against CMV. Congenital infection by CMV can result in deafness and mental retardation in newborns. He is using the guinea pig model, which is the only small animal model for congenital CMV, to investigate intervention strategies against CMV. He is also employing novel non-invasive bioluminescence imaging strategies to detect virus dissemination in real time in the animal model to define viral pathogenicity factors and antiviral therapies. As part of on going studies the innate immune system of the guinea pig is being characterized to enable studies of emerging pathogens.

Research Interest

Novel vaccine strategies against viral infection; Application of real time bioluminescence  imaging of microbial infection in animal models; Antiviral strategies against cytomegalovirus and other herpesviruses; Infectious viral bacterial artificial chromosome (BAC) technology; Adaptive and innate immunity; Animal disease models; Development of the guinea pig animal model for the study of emerging pathogens/ development of more relevant animal disease models to human infection; Real time PCR applications in viral pathogenicity/ antiviral studies.


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