alexa Fazlul H Sarkar | Wayne State University
ISSN: 2165-7092

Pancreatic Disorders & Therapy
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Fazlul H Sarkar

Fazlul H Sarkar Fazlul H Sarkar
Departments of Pathology and Oncology
Wayne State University


Dr. Sarkar is currently a Distinguished Professor, Departments of Pathology and Oncology at Karmanos Cancer Institute, Wayne State University School of Medicine. Dr. Sarkar’s early research, which still continues, is focused on understanding the role of a “master” transcription factor and the regulation of its upstream and downstream signaling molecules in solid tumors, and focusing on tumor microenvironment. Moreover, his research has been directed toward elucidating the molecular mechanism(s) of action of “natural agents”, their synthetic analogues, and other synthetic small molecule inhibitors of Bcl-2 and MDM2 for cancer prevention and therapy. The discoveries from in vitro and in vivo preclinical studies led to the design and execution of multiple Phase I/II clinical trials in breast, pancreas and prostate cancer for assessing the effects of several “natural agents” in the alterations of biomarkers as well as some early clinical efficacy testing. Dr. Sarkar’s research led to the concept of chemo-sensitization of cancer cells by reversing their drug-resistance phenotype to conventional therapeutics (chemo-radio-therapy), and all of which has been focused on tumor microenvironment, which led to clinical trials conducted at the Karmanos Cancer Institute. The innovation of his basic science research has attracted clinicians to collaborate with him, which clearly documents his leadership in translational research. Dr. Sarkar’s collaborations with basic scientists and physician scientists at MD Anderson Cancer Center led him to become a project leader for the Pancreas Cancer SPORE grant of MD Anderson Cancer Center under the leadership of Dr. James Abbruzzese, and Dr. Sarkar also served as a co-investigator for the University of Michigan Head and Neck Cancer SPORE grant.

Research Interest

Dr. Sarkar’s expertise in the field of cancer biology, cancer drug discovery, experimental therapeutics, medicinal chemistry, molecular mechanism of tumor aggressiveness with the tumor microenvironment, pre-clinical model research and conducting clinical trials. In addition, his experience is worth noticing in leading basic and clinical scientists to translate discoveries to early phase investigator-initiated clinical trials. Lastly, Dr. Sarkar’s activities clearly document his leadership expertise, and he really earned his well-deserved national and international stature in cancer research and drug discovery specifically focusing on conditioning the tumor microenvironment.


Global Speakers in the subject

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Differential Expression of MicroRNAs in Tissues and Plasma Co-exists as a Biomarker for Pancreatic Cancer
Shadan Ali, Hala Dubaybo, Randall E Brand, Fazlul H Sarkar
Research Article: J Cancer Sci Ther/Vol.7.11 336-346 (2015)
DOI: 10.4172/1948-5956.1000372
Identification of Differentially Expressed MiRNAs in Appendiceal Mucinous Cystadenocarcinoma from Mucinous Cystadenoma
Richard Licheng Wu, Shadan Ali, Fazlul H Sarkar, Rafic Beydoun
Research Article: J Cancer Sci Ther/Vol.7.11 328-335 (2015)
DOI: 10.4172/1948-5956.1000371
Comparative Analysis of Differentially Expressed miRNAs and their Downstream mRNAs in Ovarian Cancer and its Associated Endometriosis
Richard Licheng Wu, Shadan Ali, Sudeshna Bandyopadhyay, Baraa Alosh, Kinda Hayek, MHD Fayez Daaboul, Ira Winer, Fazlul H Sarkar and Rouba Ali-Fehmi
Research Article: J Cancer Sci Ther/Vol.7.8 258-265 (2015)
DOI: 10.4172/1948-5956.1000359
Notch Signaling Pathway in Pancreatic Cancer Progression
Jia Ma, Jun Xia, Lucio Miele, Fazlul H Sarkar and Zhiwei Wang
Review Article: Pancreat Disorders Ther 2013, 3: 114
DOI: 10.4172/2165-7092.1000114
Systems and Network Pharmacology Approaches to Cancer Stem Cells Research and Therapy
Irfana Muqbil, Ginny W Bao, Rkya El-Kharraj, Minjel Shah, Ramzi M Mohammad, Fazlul H Sarkar and Asfar S Azmi
Review Article: J Stem Cell Res Ther 2012, S7-005
DOI: 10.4172/2157-7633.S7-005
Identifying Biomarkers and Drug Targets Using Systems Biology Approaches for Pancreatic Cancer
Yi Tan, Lucio Miele, Fazlul H Sarkar and Zhiwei Wang
Editorial: Pancreat Disorders Ther 2012, 2:e128
DOI: 10.4172/2165-7092.1000e128
Cancer Stem Cells: Coming of Age
Fazlul H Sarkar and Asfar S Azmi
Editorial: J Stem Cell Res Ther 2012, S7-e001
DOI: 10.4172/2157-7633.S7-e001
The Role of Cancer Stem Cells and MicroRNAs in the Development and Progression of Pancreatic Cancer
Alia Ahmed, Shadan Ali, Philip A Philip and Fazlul H Sarkar
Review Article: J Stem Cell Res Ther 2012, S7-004
DOI: 10.4172/2157-7633.S7-004
The Role of EMT in Pancreatic Cancer Progression
Qiong Wu, Lucio Miele, Fazlul H Sarkar and Zhiwei Wang
Editorial: Pancreat Disorders Ther 2012, 2:e121
DOI: 10.4172/2165-7092.1000e121
Emerging Role of MicroRNA in Pancreatic Cancer
Jun Xia, Fazlul H Sarkar and Zhiwei Wang
Editorial: Pancreat Disorders Ther 2012, 2:e114
DOI: 10.4172/2165-7092.1000e114

Pancreatic Disorders & Therapy - Cancer biology

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