alexa Fuad Fares | University of Haifa
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

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Fuad Fares

Fuad Fares Fuad Fares
Associate Professor
Department of Human Biology
Faculty of Natural Sciences
University of Haifa
Israel
Tel: 972-4-8288781
Fax: 972-4-8288763
Research Interest

In my laboratory I supervise graduate students for Ph.D and for M.Sc. thesis and the recent ongoing projects related to these fields include:
1. My lab is interested in structure - function studies of Thyrotropin (TSH); identifying protein regions which are determinants for hormone specific post-translational modifications and receptor binding/biologic activity, using site-directed mutagenesis, gene fusion and mutant cell lines. Using the molecular biology techniques I will try to study the role of oligosaccharides in the structure and function of thyrotropin (TSH). This may expand our understanding in the role of oligosaccharides in the hormone function and may lead to the development of new agonists and antagonists.
2. My lab is interested in identification of pre-apoptotic factors and characterization of their molecular pathways in human cancer cells. Recently we have concentrated in indole-derivatives, derivatives that are exist in cruciferous vegetables, natural antioxidants, medicinal plants and medicinal mushrooms. The main goal of these studies is to elucidate such a novel and powerful natural compounds that can be used as an adjuvant nutritional therapy in preventing or a delaying the progression of cancer. The efficacy of these compounds will be tested in vitro using human cancer cells and in vivo using animal models. Moreover, the molecular mechanism of action of these factors will be studied in the cells using CHIP DNA analysis. These studies may lead to better understanding the biology of human cancer and may lead to the development of new strategies for prevention and treatment of human cancer.
3. The role of hormones in cancer development; studying the role of the indolic melatonin hormone in prevention of breast and prostate cancer. Over the last 120 years, increased exposure of humans to light at night imposed a long photoperiod of about 16-18 hours of light all year long, thus contributing to a of 'loss-of-seasonality'. Recent studies have linked disruption of normal circadian rhythms, via exposure to LAN, to the development of cancer. The indolic hormone melatonin (MLT) , considered as the universal regulator of biological rhythms, was found to have oncostatic and anti-proliferative effects in both in vitro and in vivo studies. Additionally, low levels of MLT may indirectly act to increase cancer risk by modulating the secretion of hormones implicated in carcinogenesis. In the current research we will determine the impact of 'loss-of-seasonality' due to long term exposure to light at night, experienced by the majority of people in the industrialized world, on the development of breast and prostate cancer in animal models. Moreover, the impact of MLT on the uptake of chemotherapeutic drugs (e.g. tamoxifen) administered during the day or night will be examined. Taken together, the results of our studies are expected to facilitate the formulation of guidelines regarding sensible use of illumination that will minimize the current risks associated with LAN without compromising our ability to work and live in a safe environment.

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Publications

Using Human Cancer Cell Lines as In vitro Model for Testing the Efficacy of CDBPA; a New Anticancer Drug
Fuad Fares, Claus L. Jensen, Stig Larsen, Naiel Azzam, Basem Fares and Steen Lindkær-Jensen
Research Article: J Tissue Sci Eng 2016, 7:168
DOI: 10.4172/2157-7552.1000168
 
An Innovative Complex of Benzene-Poly-Carboxylic Acid and Molybdenum, for Prevention and Treatment of Radiation Dermatitis
Fuad Fares, Basem Fares, Naiel Azzam, Munir Nashashibi, Alex Nevelsky, Stig Larsen and Steen Lindkær-Jensen
Research Article: Med Chem (Los Angeles) 2015, 5: 447
DOI: 10.4172/2161-0444.1000299
 
The Anti-Carcinogenic Effect of Indole-3-Carbinol and 3, 3'-Diindolylmethane and their Mechanism of Action
Fuad Fares
Special Issue Article: Med Chem (Los Angeles) 2014, S1-002
DOI: 10.4172/2161-0444.S1-002
 
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