alexa Gene P. Siegal | University of Alabama
ISSN: 2157-7099

Journal of Cytology & Histology
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Gene P. Siegal

Gene P. Siegal Executive Editor
Gene P. Siegal
Department of Cell Biology and Surgery
University of Alabama

I am an experimental and diagnostic musculoskeletal pathologist whose research interest for nearly three decades has been a blend of basic and translational investigations.  This work has been extramurally funded by the NIH, DOD, and private philanthropic agencies and foundations. Over the last 15 years I have focused my experimental work principally in cancer gene therapy using human neoplasms as the model system.  Further, I have participated in multiple gene therapy studies utilizing a variety of distinct strategies including mutation compensation, genetic immunopotentiation, and molecular chemotherapy. My most recently funded NIH grant has as its objective the goal of testing the ability of novel armed conditionally replicating adenoviruses to block breast cancer metastasis to bone and to explore the mechanisms underlying this process.  Additionally, I have had many decades long work with animal models of human disease.  I have also served since its inception as the Principal Investigator  of the Histomorphometry and Molecular Analysis Core in the Center for Metabolic Bone Disease. 

Research Interest

Tumors of bone, cancer gene therapy, invasion and metastasis and histopathology.


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α-L-Fucose in Histology: A Part of the Cancer Glycome Hiding in Plain Sight
Jay J. Listinsky, Catherine M. Listinsky and Gene P. Siegal
Editorial: J Cytol Histol 2012, 3:e102
DOI: 10.4172/2157-7099.1000e102
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