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Dr. Gianluca Baldanzi received Ph.D in Molecular Medicine at A.Avogadro University in 2008. Currently he is an Assistant professor at “A. Avogadro” University & visiting Scientist at Queen Mary University of London.
Function and regulation of SAP gene in T lymphocyte as a regulator of DGK-A. Demonstrating that SAP mediates DGK-A inhibition upon TCR stimulation thus increasing diacylglycerol signaling and T cell responses. Role of DGK-A in cell transformation promoted by v-Src and NPM-ALK. In vitro evaluation of DGK-A as a possible pharmaceutical target for the control of tumor cell growth and dissemination. Activation of DGK-A by HGF and VEGF and molecular determinants of its interaction with Src. Other interesting fields of research: Signaling pathways promoting hepatocyte survival such as PI3K, Src and DGK regulation upon adenosine and glicine release in liver preconditioning. The anti-apoptotic and pro-differenziative proprieties of Ghrelin in myocytes.
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